USP18
| USP18 | ||||||
|---|---|---|---|---|---|---|
| Identifiers | ||||||
| Aliases | USP18, ISG43, UBP43, ubiquitin specific peptidase 18 | |||||
| External IDs | MGI: 1344364 HomoloGene: 8047 GeneCards: USP18 | |||||
| RNA expression pattern | ||||||
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| More reference expression data | ||||||
| Orthologs | ||||||
| Species | Human | Mouse | ||||
| Entrez | ||||||
| Ensembl | ||||||
| UniProt | ||||||
| RefSeq (mRNA) | ||||||
| RefSeq (protein) | ||||||
| Location (UCSC) | Chr 22: 18.15 – 18.18 Mb | Chr 6: 121.25 – 121.27 Mb | ||||
| PubMed search | [1] | [2] | ||||
| Wikidata | ||||||
| View/Edit Human | View/Edit Mouse |
Ubiquitin specific peptidase 18 (USP18), also known as UBP43, is an enzyme that in human is encoded by the USP18 gene.[3] USP18 is a member of the deubiquitinating protease family of enzymes. It is thought to remove ISG15 adducts from a broad range of protein substrates, a process known as deISGylation.[3]
References
Further reading
- Li XL, Blackford JA, Judge CS, et al. (2000). "RNase-L-dependent destabilization of interferon-induced mRNAs. A role for the 2-5A system in attenuation of the interferon response.". J. Biol. Chem. 275 (12): 8880–8. doi:10.1074/jbc.275.12.8880. PMID 10722734.
- Schwer H, Liu LQ, Zhou L, et al. (2000). "Cloning and characterization of a novel human ubiquitin-specific protease, a homologue of murine UBP43 (Usp18).". Genomics. 65 (1): 44–52. doi:10.1006/geno.2000.6148. PMID 10777664.
- Kang D, Jiang H, Wu Q, et al. (2001). "Cloning and characterization of human ubiquitin-processing protease-43 from terminally differentiated human melanoma cells using a rapid subtraction hybridization protocol RaSH.". Gene. 267 (2): 233–42. doi:10.1016/S0378-1119(01)00384-5. PMID 11313150.
- Malakhov MP, Malakhova OA, Kim KI, et al. (2002). "UBP43 (USP18) specifically removes ISG15 from conjugated proteins.". J. Biol. Chem. 277 (12): 9976–81. doi:10.1074/jbc.M109078200. PMID 11788588.
- Tokarz S, Berset C, La Rue J, et al. (2004). "The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCFSkp2 ubiquitin ligase.". J. Biol. Chem. 279 (45): 46424–30. doi:10.1074/jbc.M403189200. PMID 15342634.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930
. PMID 15489336. - Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Yan M, Luo JK, Ritchie KJ, et al. (2007). "Ubp43 regulates BCR-ABL leukemogenesis via the type 1 interferon receptor signaling.". Blood. 110 (1): 305–12. doi:10.1182/blood-2006-07-033209. PMC 1896118. PMID 17374743.
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